THCA is the most abundant of all cannabinoids, with a unique compound that is not psychoactive and is beneficial from a medical point of view. Cannabis herb contains hundreds of special medicinal chemicals that fall into several categories, including cannabinoids, terpenes and flavonoids. Cannabinoids include cannabidiol (CBD) and tetrahydrocannabinol (THC), the infamous molecule responsible for most of the psychoactive effect and euphoria produced by this controversial plant that is also, technically, a vegetable. How can cannabis flowers that contain absolutely no THC deliver the same molecule to specialized receptors in the human brain and central nervous system? This is produced through a process called decarboxylation, during which tetrahydrocannabinolic acid (THCA), a non-psychoactive chemical cousin of THC, undergoes molecular metamorphosis to lose two oxygen atoms and is transformed into an element with a different binding affinity with the specialized receptors of the human endocannabinoid system.
This modified binding affinity is sufficient to produce a markedly different efficacy than THC versus THCA. A useful mental model is to think of THCA as the early-stage caterpillar that turns into a butterfly called THC. THCA is also broken down into THC through chemical processes other than decarboxylation, including oxidation and simple exposure to light. Many members of the patient community juice the leaves of cannabis plants in a strategic effort to collect as much THCA as possible.
Some claim to have gained significant benefits from regular consumption of THCA for conditions ranging from chronic pain to depression, social anxiety and fibromyalgia. The anti-inflammatory properties of THCA are useful in treating diseases such as arthritis and lupus. The neuroprotective properties of this element of the cannabis plant are useful in the treatment of neurodegenerative diseases, while its antiemetic characteristics treat nausea and loss of appetite associated with conditions such as cancer (chemotherapy) and Crohn's disease. The antiproliferative properties of THCA have been observed in studies on prostate cancer, insomnia, muscle spasms and pain.
Celebrate 7 days a week with the Guide for fans of cannabis concentrates. The days when you were only looking for the highest THC totals are quickly disappearing, as research has shown that terpenes are the basis of the entourage effect that customers want, are quickly fading. Space Coyote, the totally cosmic cannabis company, has launched the Sativa Preservation Society Project, a movement that protects the genetics of Haze and, at the same time, pays homage to the guardians and growers who kept the seeds alive. Celebrators of the smoking heritage, cannabis culture, aesthetics and spirit of Space Coyote embrace the vibrations and psychedelic scene of the seventies, where creativity and the cannabis community intersect.
Libby Cooper, co-founder and confessed of “Sativa Diva”, calls it the “project of ultimate passion”. The stars aligned earlier this year when the team met Bam Vachher-Gnanathurai, director of nurseries and plant breeding at the Possible Project in Salina. The mutual love for the unique effects of Haze genetics resulted in a truly cosmic result. The Sativa Preservation Society project launches with three incredibly rare cultivars: Cuban Black Haze, Uptown Haze (also known as A5 Haze) and C5 Haze, all of which were originally cultivated in the 1980s by legendary grower Neville Schoenmaker.
The flower will be available in the form of eighths in bags and in the form of infused pre-olles. Cooper compares the Haze experience to being “a bit like mushrooms”: the colors are brighter, the smell is better and the hearing is sharper. Learn more about the Sativa Preservation Society Project in the video above. By the way, find your closest Space Coyote here.
If you're looking for a premium strain with legendary genetics and a euphoric effect, look no further: Peach Oz, the latest addition to Wonderbrett's stellar variety chart. A cross between Peach Rings with OZ Kush and a descendant of Zkittlez, the sweet and stimulating citrus flavor profile of Peach Oz will get your creativity flowing. While the cultivar may be new to the public, according to the co-founder of Wonderbrett and famous breeder, Brett Feldman, he has been in the world of genetics for five years. Grown in small batches on a large scale at the company's modern cultivation facility in Long Beach, it was first created by Dying Breed Seeds and then refined by Cannabis By Corey before arriving at Feldman.
Peach OZ is available at a select dispensary and at Wonderbrett's flagship dispensary in Los Angeles. By Bonnie Johnson, MS, RDNCRx MagazineVol. It is characterized by a series of feelings that range from general malaise to panic, as well as a series of physical responses that range from an increase in heart rate to fleeing from a threat. Anxiety is considered pathological when the emotional response is disproportionate in duration, frequency, or intensity with respect to the cause and interferes with a person's ability to live a normal life.2 The ICD-10 definition of generalized anxiety disorder (GAD) begins with “a condition characterized by excessive worry and feelings of fear, dread, and restlessness that last for six months or more.”.
Anxiety symptoms vary from person to person and can be episodic or chronic. Left untreated, anxiety can disrupt daily life with symptoms of physical illnesses, such as abdominal pain and headaches, as well as emotional responses, such as not being able to get out of bed in the morning or limiting social interactions. The ECS and anxiety The ECS was discovered in 1992 at the Hebrew University of Jerusalem. It is described as a signaling system composed of the CB1 and CB2 cannabinoid receptors; their ligands, the endocannabinoids anandamide (N-arachidonoylethanolamide or AEA) and 2-AG (2-arachidonoylglycerol); and transport proteins and associated degrading enzymes.
The ECS performs multiple tasks, but its objective is always to maintain a stable environment despite fluctuations in the external environment. 6 Research continues to support the participation of the ECS in a variety of biological functions, such as energy expenditure, food intake, pain perception, inflammation, cognition, and responses to stress, such as anxiety. The high level of expression of CB1 receptors in areas of the brain involved in the regulation of cognitive functions and mood (amygdala, prefrontal cortex and hippocampus) implies that the ECS is involved in emotional processing and in the regulation of mood and anxiety, which means that ECS dysregulation may be an underlying cause of anxiety disorders. Other data from preclinical studies suggest that THCA may be an anti-inflammatory compound that protects against cancer, but this work does not provide a convincing explanation of the clinical reports.
Instead of producing THC and CBD directly, it synthesizes tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA) from its cannabigerolic acid (CBGA) precursor. While this is an important finding, it still doesn't fully respond to how these cannabinoids help human health, and more studies on THCA are needed. Another study suggested that THCA was a much weaker antioxidant than THC or CBD, and that THCA is only mildly neuroprotective at equally high doses. Goldstein told Project CBD that daily consumption of 10 to 20 mg of THCA was effective in reducing pain in some of his patients with arthritis and irritable bowel syndrome.
THCA can reach levels greater than 30 percent of the dry weight of unpollinated (sensitive) female flowers. Some US outlets. UU. they have started selling THCA products without a prescription, without the need for a medical card, but ultimately this depends on local and state laws and should not be taken as collateral.
But it could also be the case that THCA acts mainly on peripheral CB1 receptors outside the brain and central nervous system. Rock said that they are not sure how THCA prevents nausea and that it is very possible that this is a peripheral or off-target effect. Upon contact with heat, such as the lighter, the vaporizer battery, or quartz nails, THCA will immediately begin to convert to THC. In a patient with Alzheimer's disease, THCA improved cognitive symptoms and allowed the patient to reduce the use of other drugs.
Two studies on inflammation revealed that THCA does not inhibit COX-2, an inflammatory enzyme blocked by ibuprofen and aspirin, and high doses of THCA were needed to obtain an anti-inflammatory effect. So how does THCA confer its effects? Through which biochemical channels does THCA act? The only receptor that THCA is known to bind powerfully to is TRPM8, the receptor that makes peppermint feel cold.